Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.2
USERS' SCORE
Good
Based on 9 Reviews
8.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
L-Carnitine (Carnipure) (from L-Carnitine Tartrate)
500 mg
*
Top Medical Research Studies
9
We explored the relationship between circulating L-carnitine levels and the risk of neuromyelitis optica spectrum disorders (NMOSD) using data from genetic studies.
Our findings indicate that higher levels of L-carnitine may protect against NMOSD, specifically in patients who are negative for aquaporin-4 antibodies. However, there's no causal effect on the seropositive type of NMOSD.
This suggests that while L-carnitine could be a potential biomarker and therapeutic target, its effectiveness may vary depending on the patient subtype.
Our findings indicate that higher levels of L-carnitine may protect against NMOSD, specifically in patients who are negative for aquaporin-4 antibodies. However, there's no causal effect on the seropositive type of NMOSD.
This suggests that while L-carnitine could be a potential biomarker and therapeutic target, its effectiveness may vary depending on the patient subtype.
Read More
8
l-carnitine shows modest benefits
This study looked at how l-carnitine might help prevent muscle wasting in patients with Pemphigus Vulgaris, an autoimmune disease treated with glucocorticoids.
We administered l-carnitine or a placebo to 44 participants over eight weeks while measuring their muscle metabolism markers.
While the results showed some positive changes in markers like IGF-1 and myostatin, there were no significant differences between the l-carnitine and placebo groups.
Ultimately, l-carnitine appears to benefit muscle metabolism and regeneration but may not be markedly more effective than placebo.
We administered l-carnitine or a placebo to 44 participants over eight weeks while measuring their muscle metabolism markers.
While the results showed some positive changes in markers like IGF-1 and myostatin, there were no significant differences between the l-carnitine and placebo groups.
Ultimately, l-carnitine appears to benefit muscle metabolism and regeneration but may not be markedly more effective than placebo.
Read More
8
ALC promotes remyelination, improves motor function
We explored how acetyl-L-carnitine (ALC) might aid recovery in a mouse model of multiple sclerosis, a debilitating autoimmune disorder. Using a controlled study with three groups, we assessed the effects of ALC on coordination and balance in mice subjected to cuprizone diet for 12 weeks.
Our findings showed that mice receiving ALC demonstrated improved motor skills and remyelination in the corpus callosum. ALC helped reduce harmful free radicals and boosted specific myelin-related genes, indicating its potential as a therapeutic antioxidant for myelin repair.
Our findings showed that mice receiving ALC demonstrated improved motor skills and remyelination in the corpus callosum. ALC helped reduce harmful free radicals and boosted specific myelin-related genes, indicating its potential as a therapeutic antioxidant for myelin repair.
Read More
Most Useful Reviews
9
Increased energy levels
55 people found this helpful
L-carnitine acts as a battery for the body! I used it for a month (1 capsule 500 mg daily) to recover from covid, not for weight loss. It significantly aided my digestive tract and nervous system, alleviating severe fatigue. I now have energy to walk and exercise, and the weight loss of 4 kg has been a bonus. My husband takes it too for fertility support. Following doctor recommendations, I'll also give it to my daughter, who is struggling with energy post-covid. I trust this product and have ordered it multiple times.
Read More
9
Effective for weight loss
My husband started taking L-carnitine for weight management, and within three weeks, he saw excellent results—losing excess weight and enhancing muscle definition. The dosage is convenient, although the container only holds 60 capsules. Still, it serves our needs well, and I recommend L-carnitine for a natural weight loss approach.
Read More
6
Reduces fatigue
13 people found this helpful
Wonderful L-Carnitine! I ordered it for myself and have no regrets. This supplement is crucial not only for athletes but also for the elderly, as it reduces both physical and mental fatigue. It preserves muscle tone and enhances heart function, especially under stress, while also cleansing the body. I highly recommend it!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.2
- All Researches
9
We explored the relationship between circulating L-carnitine levels and the risk of neuromyelitis optica spectrum disorders (NMOSD) using data from genetic studies.
Our findings indicate that higher levels of L-carnitine may protect against NMOSD, specifically in patients who are negative for aquaporin-4 antibodies. However, there's no causal effect on the seropositive type of NMOSD.
This suggests that while L-carnitine could be a potential biomarker and therapeutic target, its effectiveness may vary depending on the patient subtype.
Our findings indicate that higher levels of L-carnitine may protect against NMOSD, specifically in patients who are negative for aquaporin-4 antibodies. However, there's no causal effect on the seropositive type of NMOSD.
This suggests that while L-carnitine could be a potential biomarker and therapeutic target, its effectiveness may vary depending on the patient subtype.
Read More
9
3,3-Dimethyl-1-butanol's anti-inflammatory effects
We investigated the effects of 3,3-dimethyl-1-butanol (DMB) on collagen-induced arthritis (CIA), an autoimmune condition. Our experiments revealed that DMB significantly reduced arthritis severity by over 50%, regardless of its role in trimethylamine production, a compound linked to inflammation.
Surprisingly, DMB worked independently of the gut microbiome. We identified a new metabolite from DMB, 3,3-dimethyl-1-butyric acid (DMBut), which also showed positive effects against inflammation. Together, these findings suggest that DMB and its metabolites offer a new way to manage autoimmune arthritis through immune system modulation.
Surprisingly, DMB worked independently of the gut microbiome. We identified a new metabolite from DMB, 3,3-dimethyl-1-butyric acid (DMBut), which also showed positive effects against inflammation. Together, these findings suggest that DMB and its metabolites offer a new way to manage autoimmune arthritis through immune system modulation.
Read More
9
L-Carnitine aids in arthritis treatment
We explored the effects of combining L-carnitine and zinc with methotrexate (MTX) to address gastrointestinal toxicity during arthritis treatment. Conducted on Wistar rats, the study assessed various treatments for their ability to counteract MTX-related intestinal damage while enhancing anti-arthritic benefits.
We found that the combination of zinc and L-carnitine notably reduced oxidative stress and inflammation associated with MTX, activating protective signaling pathways. Overall, this approach shows promise in balancing effective arthritis management with reduced gastrointestinal side effects.
We found that the combination of zinc and L-carnitine notably reduced oxidative stress and inflammation associated with MTX, activating protective signaling pathways. Overall, this approach shows promise in balancing effective arthritis management with reduced gastrointestinal side effects.
Read More
9
We identified that L-carnitine levels play a role in immune checkpoint inhibitor (ICI) induced myasthenia gravis (MG), a serious immune-related side effect. Through comparative genomic analysis of a thymoma patient, we discovered a genetic variant linked to this condition. Remarkably, when this patient underwent ICI treatment again with L-carnitine pretreatment, they experienced a notable response without any MG symptoms returning. This finding offers a promising glimpse into personalized treatment strategies for managing adverse effects associated with cancer therapies.
Read More
8
l-carnitine shows modest benefits
This study looked at how l-carnitine might help prevent muscle wasting in patients with Pemphigus Vulgaris, an autoimmune disease treated with glucocorticoids.
We administered l-carnitine or a placebo to 44 participants over eight weeks while measuring their muscle metabolism markers.
While the results showed some positive changes in markers like IGF-1 and myostatin, there were no significant differences between the l-carnitine and placebo groups.
Ultimately, l-carnitine appears to benefit muscle metabolism and regeneration but may not be markedly more effective than placebo.
We administered l-carnitine or a placebo to 44 participants over eight weeks while measuring their muscle metabolism markers.
While the results showed some positive changes in markers like IGF-1 and myostatin, there were no significant differences between the l-carnitine and placebo groups.
Ultimately, l-carnitine appears to benefit muscle metabolism and regeneration but may not be markedly more effective than placebo.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Increased energy levels
55 people found this helpful
L-carnitine acts as a battery for the body! I used it for a month (1 capsule 500 mg daily) to recover from covid, not for weight loss. It significantly aided my digestive tract and nervous system, alleviating severe fatigue. I now have energy to walk and exercise, and the weight loss of 4 kg has been a bonus. My husband takes it too for fertility support. Following doctor recommendations, I'll also give it to my daughter, who is struggling with energy post-covid. I trust this product and have ordered it multiple times.
Read More
9
Effective for weight loss
My husband started taking L-carnitine for weight management, and within three weeks, he saw excellent results—losing excess weight and enhancing muscle definition. The dosage is convenient, although the container only holds 60 capsules. Still, it serves our needs well, and I recommend L-carnitine for a natural weight loss approach.
Read More
6
Reduces fatigue
13 people found this helpful
Wonderful L-Carnitine! I ordered it for myself and have no regrets. This supplement is crucial not only for athletes but also for the elderly, as it reduces both physical and mental fatigue. It preserves muscle tone and enhances heart function, especially under stress, while also cleansing the body. I highly recommend it!
Read More
8
Enhanced energy levels
1 people found this helpful
This is not my first order; I take L-carnitine myself and also for my spouse before morning training. The effects are noticeable within 4-5 days—I have more energy and feel less drowsy. I recommend it!
Read More
6
Supports gut health
1 people found this helpful
I have an autoimmune disorder and take L-Carnitine to aid in healing my leaky gut.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Hu W, Hu Y, Li J, Men Y, Xia J, et al. Effect of L-Carnitine Level on the Risk of Neuromyelitis Optica Spectrum Disorders: A Two-Sample Mendelian Randomization Study. Mol Neurobiol. 2025;62:5133. doi:10.1007/s12035-024-04607-5
- Fechtner S, Allen BE, Chriswell ME, Jubair WK, Robertson CE, et al. 3,3-Dimethyl-1-Butanol and its Metabolite 3,3-Dimethylbutyrate Ameliorate Collagen-induced Arthritis Independent of Choline Trimethylamine Lyase Activity. Inflammation. 2024. doi:10.1007/s10753-024-02126-y
- Katturajan R, Evan Prince S. Zinc and L-carnitine combination with or without methotrexate prevents intestinal toxicity during arthritis treatment via Nrf2/Sirt1/Foxo3 pathways: an In vivo and molecular docking approach. Inflammopharmacology. 2023;31:2599. doi:10.1007/s10787-023-01280-3
- Noormohammadi Z, Arghavani H, Javanbakht M, Daneshpazhooh M, Jalili M. l-carnitine downregulate the muscle wasting effect of glucocorticoids in pemphigus patient: A randomized double-blind placebo-controlled study. Physiol Rep. 2023;11:e15657. doi:10.14814/phy2.15657
- Zhang Q, Zhu Y, Lv C, Fang Y, Liao M, et al. AhR activation promotes Treg cell generation by enhancing Lkb1-mediated fatty acid oxidation via the Skp2/K63-ubiquitination pathway. Immunology. 2023;169:412. doi:10.1111/imm.13638
- Teixeira CF, Azzolin VF, Rodrigues Dos Passos G, Turra BO, Alves AO, et al. A coffee enriched with guarana, selenium, and l-carnitine (GSC) has nutrigenomic effects on oxi-inflammatory markers of relapsing-remitting multiple sclerosis patients: A pilot study. Mult Scler Relat Disord. 2023;71:104515. doi:10.1016/j.msard.2023.104515
- Gao W, Wu L, Jin S, Li J, Liu X, et al. Rechallenge of immune checkpoint inhibitors in a case with adverse events inducing myasthenia gravis. J Immunother Cancer. 2022;10. doi:10.1136/jitc-2022-005970
- Gharighnia S, Omidi A, Ragerdi Kashani I, Sepand MR, Pour Beiranvand S. Ameliorative effects of acetyl-L-carnitine on corpus callosum and functional recovery in demyelinated mouse model. Int J Neurosci. 2024;134:409. doi:10.1080/00207454.2022.2107515
- Badreldeen A, El Razaky O, Erfan A, El-Bendary A, El Amrousy D. Comparative study of the efficacy of captopril, simvastatin, and L-carnitine as cardioprotective drugs in children with type 1 diabetes mellitus: a randomised controlled trial. Cardiol Young. 2021;31:1315. doi:10.1017/S1047951121000226
